曾宪思，博士，副教授，硕士生导师。2014年毕业于昆明理工大学环境生物学专业（硕博连读），获博士学位，同年入职信阳师范大学，2020年调入嘉兴大学。入选嘉兴市“创新嘉兴·精英引领计划”领军人才(青年A类)，嘉兴市首届“星耀南湖”领军人才创新团队(A类)核心成员，美国Washington University in St. Louis访问学者，中国生物化学与分子生物学学会会员，American Society of Neurochemistry会员，SCI期刊Frontiers in Cellular Neuroscience编委，Journal of Translational Medicine、Molecular Neurobiology、BBA-Molecular Basis of Disease、Molecular Nutrition & Food Research等著名SCI期刊特邀审稿人。近年来主持国家自然科学基金等项目多项。发表论文40余篇，其中SCIE收录论文近30篇，入选ESI高被引论文1篇；获得省级优秀科技论文奖一等奖2项、二等奖1项。指导本科生国家级大学生创新创业训练计划项目1项，获省级学科竞赛二等奖和三等奖各1项。

主持项目:

1.国家自然科学青年基金项目，31600837，2017/01-2019/12，18万。

2.嘉兴市公益性研究项目，2021AY30001，2021/01-2023/12，10万。

3.浙江省基础公益研究项目，LTGY23C090001，2023/01-2025/12，10万。

4.嘉兴市“创新嘉兴·精英引领计划”领军人才(青年A类)，80万。

5.嘉兴大学“勤慎青年骨干”培养项目，2023.08-2026.07，4万。

代表论文（近五年）：

1.张钰倩，姜文君，吕昊，盛子轩，黄子芸，柴文敏，肖婧，李阳，李丽，曾宪思*.甘草酸抑制C57BL/6J小鼠耳蜗炎症减轻顺铂诱导的耳毒性.中国病理生理杂志，2024，40(2)：291-300. (一级期刊)

2.Rou Gu, Liping Bai, Fang Yan, Se Zhang, Xianwen Zhang, Ruhua Deng,Xiansi Zeng, Bo Sun, Xiaomei Hu, Ye Li, Jie Bai*. Thioredoxin-1 decreases alpha-synuclein induced by MPTP through promoting autophagy-lysosome pathway. Cell Death Discovery, 2024, 10(1): 93. (IF=7.0)

3.Xiansi Zeng, Wenshuo Geng, Yu Zhang, Jiayi Yin, Guangtao Xu, Meng Yu, Li Li, Jinjing Jia*. Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease. Ageing Research Reviews, 2023, 90:102000. (IF=13.1)

4.Yuqian Zhang, Zixuan Sheng, Jing Xiao, Yang Li, Jie Huang, Jinjing Jia,Xiansi Zeng*, Li Li*. Advances in the roles of glycyrrhizic acid in cancer therapy. Frontiers in Pharmacology, 2023, 14:1265172. (IF=5.6)

5.Jinjing Jia, Guangtao Xu, Dongsheng Zhu, Hongjun Liu,Xiansi Zeng*, Li Li*. Advances in the Functions of Thioredoxin System in Central Nervous System Diseases. Antioxidants Redox Signaling, 2023, 38(4-6):425-441. (IF=7.468)

6.Yang Zhang, Yuechen Chang, Ziwei Han, Ketao Ma,Xiansi Zeng*, Li Li*. Estrogen Protects against Renal Ischemia-Reperfusion Injury by Regulating Th17/Treg Cell Immune Balance. Disease Markers, 2022, 2022: 7812099. (IF=3.464)

7.Liang Gong Jiayi Yin, Yu Zhang, Ren Huang, Yuxuan Lou, Haojie Jiang, Liyan Sun, Jinjing Jia*,Xiansi Zeng*. Neuroprotective Mechanisms of Ginsenoside Rb1 in Central Nervous System Diseases. Frontiers in Pharmacology, 2022, 13: 914352. (IF=5.988)

8.Jinjing Jia, Xinhong Zhang, Guangtao Xu,Xiansi Zeng*,Li Li*. Thioredoxin-1 inhibits amyloid-β25-35-induced activation of NLRP1/caspase-1/GSDMD pyroptotic pathway in PC12 cells. Molecular Biology Reports, 2022, 49(5):3445-3452. (IF=2.742)

9.Jinjing Jia,Xiansi Zeng*, Guangtao Xu, Zhanqi Wang. The Potential Roles of Redox Enzymes in Alzheimer’s Disease: Focus on Thioredoxin. ASN Neuro, 2021, 13: 1759091421994351. (IF=4.167)

10.Devin M. Barry, Xue-Ting Liu, Benlong Liu, Xian-Yu Liu, Fang Gao,Xiansi Zeng, Juan Liu, Qianyi Yang, Steven Wilhelm, Jun Yin, Ailin Tao, Zhou-Feng Chen*. Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors. Nature Communications, 2020, 11: 1397. (IF=14.919)

英文著作：

1.《The Biology of Morphine and Oxidative Stress》. Chapter in Handbook of Substance Misuse and Addictions: From Biology to Public Health, Springer Nature, 2022.

获奖情况：

1.Gensenoside Rb1 protects rat PC12 cells from oxidative stress induced endoplasmic reticulum stress: the involvement of thioredoxin-1,河南省教育厅优秀科技论文奖，一等奖，2019.5，1/3。

联系方式：

Email: xszeng@zjxu.edu.cn；zxs-2005@vip.163.com