汪瑱,博士,主管药师。2013-2017年就读于山东大学药学院药学专业,获学士学位,2017-2022年就读于中国药科大学药学院药剂学专业(硕博连读),获博士学位,同年入职嘉兴市第一医院。
研究方向与领域:药物新制剂与新技术。结合临床需求,围绕脂质纳米颗粒、药物靶向递送、黏膜与皮肤促渗等技术,为恶性肿瘤和过敏性疾病等防治提供创新制剂平台。
科研成果:主持浙江省自然科学基金1项,嘉兴市科技计划1项,嘉兴市第一医院/嘉兴学院附属医院联合科研基金1项,参与国家自然科学基金2项。以第一作者在Biomaterials、J Control Release、Frontiers in immunology等期刊发表SCI论文6篇(2篇IF>10)。申请6项中国专利,授权2项。
主持项目:
1)浙江省自然科学基金资助项目,LQ24H300002,核壳型速溶微针介导靶向疫苗联合雷西莫特用于表皮脱敏治疗的研究,2024-01-01至2026-12-31,10万元,在研,主持
2)嘉兴市公益性研究计划,2023AY11012,靶向朗格汉斯细胞的相变纳米纤维贴用于表皮脱敏治疗的研究,2023-03-01至2025-12-31,20万元,在研,主持
3) 嘉兴市第一医院2022 年度“启明星”人才工程培养计划,2022-10-01至2025-09-30,20万元,在研,主持
4)嘉兴市第一医院/嘉兴大学附属医院联合科研基金项目,2023LHJJ002,纳米纤维贴用于表皮免疫治疗的研究,2023-11-01至2025-10-31,6万元,在研,主持
代表论文(近五年):
1) Zhen Wang, Hao Cheng, Yu Sheng, Zongkai Chen, Xiaohong Zhu, Jianye Ren, Xiangze Zhang, Lingyu Lv, Huaqing Zhang, Jianping Zhou*, Yang Ding*. Biofunctionalized Graphene Oxide Nanosheet for Amplifying Antitumor Therapy: Multimodal High Drug Encapsulation, Prolonged Hyperthermal Window, and Deep-site Burst Drug Release. Biomaterials, 287 (2022) 1216293 (第一,IF: 15.304)
2) Zhen Wang#, Bixi Ding#, Yuanpei Zhao, Yue Han, Yu Sheng, Ling Tao, Xiangchun Shen, Jianping Zhou*, Lei Jiang*, Yang Ding*. Tumor-oriented mathematical models in hydrogel regulation for precise topical administration regimens. Journal of Controlled Release, 345 (2022) 610-624. (第一,IF: 11.467)
3)Zhen Wang, Qing Gao, Bailong Hou, Wei Wang, Liya Xu, and Wei Wang. One-Step Synthesis of Silver Nanoparticles Embedded in Biobased Polyamide 56 Nanofibers with High Antibacterial Activity. ACS Omega, 2024, 9 (17), 19272-19281(第一,IF: 4.1)
4) Zhen Wang, Lingzhi Wu, Wei Wang. Innovative delivery systems for epicutaneous immunotherapy. Frontiers in immunology, 14 (2023) 1238022(第一,IF: 7.3)
5) 汪瑱,董威,何家杨,汪蔚,经皮免疫治疗的临床和动物研究进展,中华临床免疫和变态反应杂志,2023,17(6): 569-578
6)Yu Sheng#, Zhen Wang#, Gella Maelys Ngandeu Neubi, Hao Cheng, Chenshuang Zhang, Huaqing Zhang, Ruoning Wang, Jianping Zhou* and Yang Ding*. Lipoprotein-inspired penetrating nanoparticles for deep tumor-targeted shuttling of indocyanine green and enhanced photo-theranostics. Biomaterials Science, 2019, 7(8): 3425-3437 (共一,IF: 6.183)
7) Hao Cheng#, Khalid Gadora#, Zhen Wang#, Huaqing Zhang, Wenxin Jiang, Xin Chen, Guochen Han, Yi Jin, Jianping Zhou*, Lei Jiang*, Yang Ding*. Functionalized nanographene oxide in biomedicine applications: bioinspired surface modifications, multidrug shielding, and site-specific trafficking. Drug Discovery Today, 2019, 24(3): 749-762(共一,IF: 7.32)
8) Hao Cheng, Xin Chen, Yu Sheng, Mingjie Song, Chenkai Sun, Zhen Wang, Jianping Zhou*, Huaqing Zhang*, Yang Ding*. Perovskite-derived pro-photosensitizer enables sustainable photodynamic therapy in hypoxia tumors. Chemical Engineering Journal. 2023,468:143457. (第六,IF: 16.744)
9) Lingyu Lv, Hao Cheng, Zhen Wang, Zhangyi Miao, Feng Zhang, Jie Chen, Gang Wang, Ling Tao, Jianping Zhou, Huaqing Zhang* and Yang Ding*. “Carrier-drug” layer-by-layer hybrid assembly of biocompatible polydopamine nanoparticles to amplify photo-chemotherapy. Nanoscale, 2022,14, 13740-13754. (第三,IF: 8.307)
10) Hao Cheng, Zijun Jiang, Chenkai Sun, Zhen Wang, Guochen Han, Xin Chen, Tianyi Li, Zhechen Fan, Feng Zhang, Xiaoyu Yang, Lingyu Lv, Huaqing Zhang, Jianping Zhou, Yang Ding*. Protein stabilized polymeric nanoparticles inspired relay drug delivery for tackling post-chemotherapeutic metastasis. Chemical Engineering Journal. 2022, 427: 131672. (第四,IF: 16.744)
11) Huaqing Zhang#, Yi Jin#, Cheng Chi#, Guochen Han#, Wenxin Jiang#, Zhen Wang, Hao Cheng, Chenshuang Zhang, Gang Wang, Chenhua Sun, Yun Chen, Yilong Xi, Mengting Liu, Xie Gao, Xiujun Lin, Lingyu Lv, Jianping Zhou*, Yang Ding*. Sponge particulates for biomedical applications: Biofunctionalization, multi-drug shielding, and theranostic applications. Biomaterials. 2021, 273: 120824. (第六,IF: 15.304)
12) Hao Cheng#, Huaqing Zhang#, Gujun Xu, Jin Peng, Zhen Wang, Bo Sun, Djamila Aouameur, Zhechen Fan, Wenxin Jiang, Jianping Zhou*, Yang Ding*. A Combinative Assembly Strategy Inspired Reversibly Borate-Bridged Polymeric Micelles for Lesion-Specific Rapid Release of Anti-Coccidial Drugs, Nano-Micro Letters, 2020, 12(11): 168-186. (第五,IF: 16.418)
授权专利:
1)丁杨; 周建平; 汪瑱; 一种用于表皮脱敏治疗的相变同轴纳米纤维膜及其制备方法和应用, 2023-2-24, 中国, CN202111254586.0
2) 丁杨; 周建平; 陈宗凯; 汪瑱; 一种用于表皮脱敏治疗的离子液体-反相胶束载药递释系统及其制备方法和应用, 2023-10-24, 中国, CN202111280775.5
获奖情况:
联系方式:Email: jxwangzhen@163.com