徐金标,博士,教授,硕士生导师。2014年毕业于中国科学院上海药物研究所 药物化学专业(硕博连读),获博士学位,2019年入职嘉兴大学。从事中药材中活性成分的发现及其作用机制研究,主持国家自然科学基金1项、浙江省自然科学基金1项、市重点研发项目1项。以第一或通讯作者在Breast Cancer Research、Journal of the American Chemical Society、Journal of Ethnopharmacology等期刊发表SCI论文20余篇,授权发明专利4项。获浙江省科技进步奖三等奖1项,一级行业协会二等奖、三等奖各1项。浙江省151人才工程第二层次人才,浙江省高校领军人才,嘉兴市杰出人才重点资助人才。
主持项目:
1. 国家自然科学基金,红豆树中金雀花碱类α4β2 nAChRs激动剂的发现、结构修饰及构效关系研究,2021.01-2023.12
2. 浙江省自然科学基金,畲药柳叶蜡梅中具有克服肿瘤多药耐药作用的生物碱类成分研究,2016.01-2018.12
代表论文(近五年):
1. Zhan-Peng Ge#, Jin-Biao Xu#, Peng Zhao, Mai Xiang, Yu Zhou, Ze-Min Lin, Jian-Ping Zuo, Jin-Xin Zhao, Jian-Min Yue*. Highly modified cephalotane-type diterpenoids from Cephalotaxus fortunei var. alpina and C. sinensis. Phytochemistry, 2024, 221: 114038.
2. Jin Biao Xu, Jun Cao, Jin Xia, Ying Zhu, Yi He, Ming Guo Cao, Bing Mu Fang, Jean Paul Thiery, Wu Zhou*. Breast metastatic tumors in lung can be substituted by lung‑derived malignant cells transformed by alternative splicing H19 lncRNA. Breast Cancer Research, 2023, 25: 59.
3. Qing-Qing Zhou, Xiao-Yan Xie, Jia-Wen Zhu, Wei-Wei Pan, Bao-Gang Xie, Wu Zhou, Jin- Biao Xu*. Hosimosines A-E, structurally diverse cytisine derivatives from the seeds of Ormosia hosiei Hemsl. et Wils. Fitoterapia, 2023, 170: 105661.
4. Ruijin Geng#, Mengjie Yu#, Jinbiao Xu#, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie*. Amino acids analysis reveals serum methionine contributes to diagnosis of the Kawasaki disease in mice and children. Journal of Pharmaceutical and Biomedical Analysis, 2023, 239: 115873.
4. Xiaoyan Xie, Qingqing Zhou, Yanting Zhou, Jinbiao Xu*. The first example of di-p-methane rearrangement in nature: Cephalotanols A and B, two novel rearranged norlignan glycosides from Cephalotaxus fortunei Hook. Records of Natural Products, 2023, 17(2): 256-264.
5. Jin-Biao Xu*, Xiao-Yan Xie, Qing-Qing Zhou, Jian-Yong Zhu*. Abieshanesides A and B, two unique ent-18,19-dinoricetexane diterpenoid glycosides from Abies beshanzuensis M.H. Wu. Fitoterapia, 2022, 156: 15096.
7. Ji-Ming Wu#, Qing-Qing Zhou#, Xiao-Yan Xie, Jin-Biao Xu*; Khayalactone- and phragmalin-type limonoids with PTP1B inhibitory activity from Trichilia sinensis Bentv, Fitoterapia, 2021, 154, 105025.
8. Jin-Biao Xu#; Guang-Chun Gao#; Ming-Jing Yuan; Xuan Huang; Hong-Yu Zhou; Yang Zhang; Ya-Xin Zheng; Zhe Wu; Jun-Miao Feng; Ji-Ming Wu*; Lignans from Schisandra chinensis ameliorate alcohol induced long term liver injury and reducing hepatocellular degeneration via blocking ETBR, Journal of Ethnopharmacology, 2020, 258: 112813.
9. 周青青,谢晓艳,张燕霞,周武,占扎君,徐金标*. 天然金雀花碱及其衍生物的化学结构和药理作用研究进展. 中国中药杂志, 2023, 48(10): 2679-2698.
授权专利:
1. 中国发明专利,柳叶蜡梅中降倍半萜类化合物的制备方法(1/2),ZL202110128752.6
2. 中国发明专利,用于治疗骨质疏松的中药组合物及其制备方法(1/4),ZL201510582201.1
获奖情况:
1. 中国商业科技进步奖三等奖:中药复方药学研究关键技术与应用,2022.12,排序1/12
2. 中国有色金属工业科技进步奖二等奖:硒元素在功能性食品中应用的关键技术及其质量控制标准,2020.12,排序8/13
联系方式:
Email: xujinbiao2015@126.cn